Coronavirus and analgesics

Analgesics and kidney disease.

The National Institutes of Health (NIH) recently issued a report stating that 'combinations of antipyretic analgesics, taken in large doses over a prolonged period, cause a specific form of kidney disease and chronic renal failure.' This hypothesis has been widely held for many years. The NIH report may faithfully describe the consensus in medicine today, but it is not informative about what is...

Opioid and Nonopioid Analgesics

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF N-METHYL PIPERIDINE ANALGESICS

Pain is probably the immediate stimulus for more visits to the Physician's office than all other complaints combined. Since pain serves as an alert to injury, it is often the first harbinger of disease. Piperidine has been extensively utilized for the synthesis of a wide range of therapeutic agents in general and analgetics in particular for the mitigation of pain. In a similar attempt, th...

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...

Topical analgesics.

BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...